After draining his life savings to enter a team in the Rucker Classic street ball tournament in Harlem, Dax (Lil Rel Howery) is dealt a series of unfortunate setbacks, including losing his team to his longtime rival (Nick Kroll). Desperate to win the tournament and the cash prize, Dax stumbles upon the man, the myth, the legend Uncle Drew (NBA All-Star Kyrie Irving) and convinces him to return to the court one more time. The two men embark on a road trip to round up Drew's old basketball squad (Shaquille O'Neal, Chris Webber, Reggie Miller, Nate Robinson, and Lisa Leslie) and prove that a group of seniors can still win the big one.
Joining G-Eazy, Yo Gotti, YBN Nahmir, A$AP Rocky, Gucci Mane, 21 Savage and London On Da Track on the all-star soundtrack are Khalid, A$AP Ferg, Tone Stith, 2 Chainz, GoldLink, Logic, French Montana, Remy Ma, Wiz Khalifa, Leikeli47, Grace and more. Making a special guest appearance on the soundtrack is none other than Uncle Drew star Kyrie Irving with LunchMoney Lewis. "It was an honor working with The Stereotypes on my first ever song," Irving said. "Being on a soundtrack with this amazing list of artists is incredibly humbling."